How LDN Works

Naltrexone, in its standard 50 mg dosage, is an opioid receptor antagonist used to treat opioid and alcohol dependence. However, when administered in much lower doses (typically 0.5 mg to 4.5 mg), LDN has been found to have unique effects on the immune system.

Mechanism of Action

  • Opioid Receptor Blockade: LDN temporarily blocks opioid receptors, stimulating the body to increase endorphin and enkephalin production. These natural peptides play a crucial role in immune regulation and pain relief.
  • Immune System Modulation: LDN has been observed to balance immune system activity, reducing excessive inflammation in autoimmune and chronic conditions.
  • Microglial Cell Regulation: In the central nervous system, LDN helps regulate microglial cells, which contribute to neuroinflammation in conditions like multiple sclerosis and fibromyalgia.